Hydrochloric Acid → HCID 18919298, compound

HRID 1291250Notes

Reaction equation

HRID 1291250 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([C:6]([C:8]2[CH:27]=[CH:26][C:11]([CH2:12][N:13]3[C:21]4[C:20](=[O:22])[N:19]([CH3:23])[C:18](=[O:24])[N:17]([CH3:25])[C:16]=4[N:15]=[CH:14]3)=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.Cl.CCOCC>CO>[ClH:1].[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([C:6]([C:8]2[CH:27]=[CH:26][C:11]([CH2:12][N:13]3[C:21]4[C:20](=[O:22])[N:19]([CH3:23])[C:18](=[O:24])[N:17]([CH3:25])[C:16]=4[N:15]=[CH:14]3)=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 18919192HCID 18919192, compound

Product 1

HCID 18919298HCID 18919298, compoundYield 154.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 7-[4-(4-chlorobenzoyl)benzyl]-1,3-dimethylxanthine (100 mg) in methanol (4 ml) was added 4N-hydrochloric acid (1 ml) and the mixture was stirred at room temperature for 10 minutes. To this reaction mixture was added ether and the resulting precipitate was collected by filtration to provide the title compound as white powder (84 mg, 77%). 1H-NMR (CDCl3) δ: 3.45(3H,s), 3.70(3H,s), 5.70(2H,s), 7.42-7.83(8H,m), 8.47(1H,s).

Workup

  1. filtrationthe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-4695a07d60f8458ca05f78a57baec617
Source dataset
uspto-grants-1998_05
Patent number
US05753664

Reaction notes

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