反应详情

To a solution of theophylline (1.80 g) in DMF (20 ml) were added potassium carbonate (1.66 g) and 4-[(1-indolyl)carbonyl]benzyl chloride (2.70 g) and the mixture was stirred at room temperature for 22 hours. This reaction mixture was diluted with water and extracted with ethyl acetate. The extract was washed with saturated aqueous NaCl solution and dried over anhydrous sodium sulfate and the solvent was distilled off to provide the title compound as colorless powder (2.25 g, 54%).

1. extractionextracted with ethyl acetate
2. washThe extract was washed with saturated aqueous NaCl solution
3. dry with materialdried over anhydrous sodium sulfate
4. distillationthe solvent was distilled off