反应详情

To a solution of 5-ethyl-6-methylthio-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (900 mg) in DMF (20 ml) was added 60% sodium hydride (207 mg) and the mixture was stirred at room temperature for 10 minutes. Then, 4-(4-methoxybenzoyl)benzyl bromide (1.31 g) was added and the mixture was further stirred at room temperature for 30 minutes. This reaction mixture was concentrated and the residue was dissolved in ethyl acetate, washed with water, dried, and concentrated. The residue was purified by silica gel column chromatography (hexane: ethyl acetate-chloroform=3:2:1) to provide the title compounds (A) (400 mg) and (B) (366 mg) both as white solid.

1. stirringthe mixture was further stirred at room temperature for 30 minutes
2. concentrationThis reaction mixture was concentrated
3. dissolutionthe residue was dissolved in ethyl acetate
4. washwashed with water
5. customdried
6. concentrationconcentrated
7. customThe residue was purified by silica gel column chromatography (hexane: ethyl acetate-chloroform=3:2:1)