反应详情

A solution of 3,5-dimethyl-2-mercapto-4(3H)quinazolinone (1.03 g), 4,4'-bis (bromomethyl)benzophenone (1.75 g), phenylpiperazine (810 mg), and 1N-sodium hydroxide/water (5.5 ml) in DMF (35 ml) was stirred at 60° C. for 1 hour. This reaction mixture was concentrated and the residue was dissolved in ethyl acetate, washed with water, dried, and concentrated. The residue was purified by silica gel column chromatography (hexane: ethyl acetate: chloroform=4:1:1) and crystallized from isopropyl ether to provide the title compound as colorless solid (372 mg).

1. concentrationThis reaction mixture was concentrated
2. dissolutionthe residue was dissolved in ethyl acetate
3. washwashed with water
4. customdried
5. concentrationconcentrated
6. customThe residue was purified by silica gel column chromatography (hexane: ethyl acetate: chloroform=4:1:1)
7. customcrystallized from isopropyl ether