反应详情

A solution of 2-mercapto-3-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (599 mg), 4-(6-chloronicotinoyl)benzyl bromide (1.179 g) and potassium carbonate (1.148 g) in DMF (40 ml) was stirred at room temperature for 2 hours. This reaction mixture was concentrated and the residue was dissolved in ethyl acetate, washed with water, dried, and concentrated. The residue was recrystallized from tetrahydrofuranethyl acetate to provide the title compound as colorless solid (367 mg).

1. concentrationThis reaction mixture was concentrated
2. dissolutionthe residue was dissolved in ethyl acetate
3. washwashed with water
4. customdried
5. concentrationconcentrated
6. customThe residue was recrystallized from tetrahydrofuranethyl acetate