反应详情

A solution of 3-methyl-7-[4-(4-chlorobenzoyl)-benzyl]xanthine (544 mg), potassium carbonate (202 mg) and isopropyl iodide (356 mg) in DMF (10 ml) was stirred at 60° C. for 5 hours. This reaction mixture was poured in water and extracted with ethyl acetate. The extract was washed with water, dried and concentrated. The residue was purified by silica gel column chromatography (hexane: ethyl acetate =1:1) and recrystallized from acetone-hexane to provide the title compound as colorless solid (38 mg).

1. extractionextracted with ethyl acetate
2. washThe extract was washed with water
3. customdried
4. concentrationconcentrated
5. customThe residue was purified by silica gel column chromatography (hexane: ethyl acetate =1:1)
6. customrecrystallized from acetone-hexane