反应详情

A solution of 3-methyl-7-[4-(4-chlorobenzoyl)-benzyl]xanthine (975 mg), sodium hydride (61 mg) and fluoromethyl bromide (121 mg) in DMF (10 ml) was stirred at 10° C. for 1 hour. This reaction mixture was poured in water and extracted with ethyl acetate. The extract was washed with water, dried, and concentrated. The residue was purified by silica gel column chromatography (hexane-ethyl acetate =1:2) and recrystallized from ethyl acetate to provide the title compound as colorless solid (121 mg).

1. extractionextracted with ethyl acetate
2. washThe extract was washed with water
3. customdried
4. concentrationconcentrated
5. customThe residue was purified by silica gel column chromatography (hexane-ethyl acetate =1:2)
6. customrecrystallized from ethyl acetate