反应详情

A solution of 1,3-dimethylxanthine (712 mg), potassium carbonate (578 mg) and 4-(6-chloronicotinoyl)benzyl bromide (1515 mg) in DMF (10 ml) was stirred at 60° C. for 5 hours. This reaction mixture was poured in water and extracted with ethyl acetate. The extract was washed with water, dried, and. concentrated. The residue was purified by silica gel column chromatography (hexane: ethyl acetate =1:3) and recrystallized from chloroform-isopropyl ether to provide the title compound as colorless solid (1562 mg).

1. extractionextracted with ethyl acetate
2. washThe extract was washed with water
3. customdried
4. concentrationconcentrated
5. customThe residue was purified by silica gel column chromatography (hexane: ethyl acetate =1:3)
6. customrecrystallized from chloroform-isopropyl ether