反应详情

A solution of 1,3-dimethylxanthine (990 mg), potassium carbonate (1348 mg) and 4-(4-bromomethylbenzoyl)benzyl bromide (2007 mg) in DMF (10 ml) was stirred at 60° C. for 5 hours. This reaction mixture was poured in water and extracted with ethyl acetate. The extract was washed with water, dried, and concentrated. The residue was purified by silica gel column chromatography (hexane: ethyl acetate =1:5) and recrystallized from ethyl acetate-isopropyl ether to provide the title compound as colorless solid (1021 mg).

1. extractionextracted with ethyl acetate
2. washThe extract was washed with water
3. customdried
4. concentrationconcentrated
5. customThe residue was purified by silica gel column chromatography (hexane: ethyl acetate =1:5)
6. customrecrystallized from ethyl acetate-isopropyl ether