反应详情

温度

80 °C

To a solution of 3,6-dimethyl-7-hydroxy-5H-thiazolo[3,2-a]pyrimidin-5-one (537 mg) and potassium carbonate (745 mg) in DMF (10 ml) was added 4-(4-methoxybenzoyl)benzyl bromide (970 mg) and the mixture was stirred at 80° C. for 2 hours. This reaction mixture was concentrated and the residue was diluted with water-ethyl acetate and extracted with ethyl acetate. The extract was purified by silica gel column chromatography (hexane: ethyl acetate =2:1) and recrystallized from ethyl acetate to provide the title compound as colorless solid (106 mg).

1. concentrationThis reaction mixture was concentrated
2. additionthe residue was diluted with water-ethyl acetate
3. extractionextracted with ethyl acetate
4. customThe extract was purified by silica gel column chromatography (hexane: ethyl acetate =2:1)
5. customrecrystallized from ethyl acetate