Potassium Carbonate → 7-[4-(4-Nitrobenzoyl)benzyloxy]-3,6-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one

HRID 1291424Notes

Reaction equation

[CH3:1][C:2]1[N:6]2[C:7](=[O:13])[C:8]([CH3:12])=[C:9]([OH:11])[N:10]=[C:5]2[S:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[N+:20]([C:23]1[CH:38]=[CH:37][C:26]([C:27]([C:29]2[CH:36]=[CH:35][C:32]([CH2:33]Br)=[CH:31][CH:30]=2)=[O:28])=[CH:25][CH:24]=1)([O-:22])=[O:21]>CN(C=O)C>[N+:20]([C:23]1[CH:24]=[CH:25][C:26]([C:27]([C:29]2[CH:36]=[CH:35][C:32]([CH2:33][O:11][C:9]3[N:10]=[C:5]4[S:4][CH:3]=[C:2]([CH3:1])[N:6]4[C:7](=[O:13])[C:8]=3[CH3:12])=[CH:31][CH:30]=2)=[O:28])=[CH:37][CH:38]=1)([O-:22])=[O:21]

Participants

Conditions

Temperature: 80 °C

Procedure

To a solution of 3,6-dimethyl-7-hydroxy-5H-thiazolo[3,2-a]pyrimidin-5-one (537 mg) and potassium carbonate (618 mg) in DMF (10 ml) was added 4-(4-nitrobenzoyl)benzyl bromide (909 mg) and the mixture was stirred at 80° C. for 2 hours. This reaction mixture was concentrated and the residue was diluted with water-ethyl acetate and extracted with ethyl acetate. The extract was purified by silica gel column chromatography (hexane: ethyl acetate =2:1) and recrystallized from ethyl acetate to provide the title compound as colorless solid (105 mg).

Workup

concentrationThis reaction mixture was concentrated
additionthe residue was diluted with water-ethyl acetate
extractionextracted with ethyl acetate
customThe extract was purified by silica gel column chromatography (hexane: ethyl acetate =2:1)
customrecrystallized from ethyl acetate

Sources & evidence

ORD record: ord-70cc3686fe8d4046a0e521f29284b8a8
Source dataset: uspto-grants-1998_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05753664

Reaction notes

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