Isopropanol → HCID 19016549, compound

HRID 1291441Notes

Reaction equation

HRID 1291441 reaction equation
[Na].Cl[C:3]1[C:7]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:6][S:5][N:4]=1.[CH:14]([OH:17])([CH3:16])[CH3:15]>>[CH:14]([O:17][C:3]1[C:7]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:6][S:5][N:4]=1)([CH3:16])[CH3:15]

Participants

4

Reactant 3

HCID 3776IsopropanolHCID 5360545SodiumHCID 104881643-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole

Product 1

HCID 19016549HCID 19016549, compoundYield 98%

Conditions

Temperature
25 °C

Procedure

To a solution of sodium (290 mg, 12.5 mmol) in isopropanol (10 ml) was added 3-(3-chloro-1,2,5-thiadiazol-4-yl)pyridine (490 mg, 2.5 mmol). The mixture was stirred at 25° C. for 18 h and evaporated. The residue was dissolved in water and extracted with ethyl acetate. The combined organic phases were dried and evaporated to yield 540 mg (98%) of the title compound.

Workup

  1. customevaporated
  2. dissolutionThe residue was dissolved in water
  3. extractionextracted with ethyl acetate
  4. customThe combined organic phases were dried
  5. customevaporated

Sources & evidence

ORD record
ord-0aa74e9c648f4debbc24281f31b4f677
Source dataset
uspto-grants-1998_05
Patent number
US05753683

Reaction notes

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