Hydrochloric Acid → HCID 18920413, compound

HRID 1291593Notes

Reaction equation

HRID 1291593 reaction equation
[CH:1]([C:3]1[S:7][C:6]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)=[CH:5][CH:4]=1)=O.[C:13]([OH:19])(=[O:18])[CH2:14][C:15]([OH:17])=[O:16].N1CCCCC1.Cl>O.N1C=CC=CC=1>[C:15]([C:14]([C:13]([OH:19])=[O:18])=[CH:1][C:3]1[S:7][C:6]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)=[CH:5][CH:4]=1)([OH:17])=[O:16]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 8082PiperidineHCID 364428[2,2'-Bithiophene]-5-carboxaldehyde

Product 1

HCID 18920413HCID 18920413, compoundYield 100.4%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1049PyridineSolvent

Procedure

3.9 g of 5-formyl-2,2'-bithiophene, 4.2 g of malonic acid, 10 ml of pyridine and 2.5 ml of piperidine were heated at 60° C. for 2 hours. After cooling, 50 ml of water was added into the mixture and acidified by diluted HCl. The crude product collected was recrystallized from ethanol to give a crystal product (5.65 g). The melting point of the product was 220°-221° C. The yield was 86%.

Workup

  1. temperatureAfter cooling
  2. customThe crude product collected
  3. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-13f1c599e97d464292695c211ecffaef
Source dataset
uspto-grants-1998_05
Patent number
US05753692

Reaction notes

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