Tris(hydroxymethyl)aminomethane → Trishydroxymethyl-aminomethane 4-hydroxybutyrate

HRID 1291685Notes

Reaction equation

HRID 1291685 reaction equation
C1(=O)OCCC1.[OH:7][CH2:8][C:9]([CH2:13][OH:14])([CH2:11][OH:12])[NH2:10].[OH:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20]>O>[OH:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20].[OH:7][CH2:8][C:9]([CH2:13][OH:14])([CH2:11][OH:12])[NH2:10]

Participants

5

Reactant 3

HCID 6503Tris(hydroxymethyl)aminomethaneHCID 7302Gamma-ButyrolactoneHCID 104134-Hydroxybutyric Acid

Product 1

HCID 86752585Trishydroxymethyl-aminomethane 4-hydroxybutyrate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
60 °C

Procedure

500 ml (565 g, 6.56 mol) of gamma-butyrolactone are placed in 1.8 l of water. 795 g (6.56 mol) of trishydroxymethylmethylamine are added to the solution obtained. The mixture is then heated to 60° C. for 8 hours. The pH value falls over this period from an initial value of 10.5 to 7.5. The volume of the solution obtained is then adjusted to 3.4 l by the addition of water in order to achieve a concentration of 2 g of gamma-hydroxybutyric acid in 10 ml of solution.

Workup

  1. customobtained
  2. waitThe pH value falls over this period
  3. customThe volume of the solution obtained

Sources & evidence

ORD record
ord-4806039ddeef49c5a219e6b2d48625a0
Source dataset
uspto-grants-1998_05
Patent number
US05753708

Reaction notes

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