Hydrochloric Acid → HCID 14585930, compound

HRID 1291716Notes

Reaction equation

HRID 1291716 reaction equation
[C:1]([CH:3](C#N)[CH2:4][NH:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][CH2:15][CH:16](C#N)[C:17]#[N:18])#[N:2].[ClH:23].[H][H]>O=[Pt]=O>[ClH:23].[ClH:23].[ClH:23].[ClH:23].[NH2:18][CH2:17][CH2:16][CH2:15][NH:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][NH:5][CH2:4][CH2:3][CH2:1][NH2:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 85571652HCID 85571652, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14585930HCID 14585930, compound

Reagents, catalysts & solvents 1

HCID 345198Adams' catalystCatalyst

Procedure

Combine 50.0 gm of the product of Example 1, 2.0 gm PtO2, 133 ml of conc. HCl at 45 lbs./sq.in. in a shaker flask until hydrogen is no longer taken up. Filter the resulting mixture, evaporate the solvent and triturate the product with 1 liter of EtOH. Filter and dry the product to obtain 51.6 gm of the title compound, Rf is 0.17 (silica gel plates eluted with 40% conc. NH3 /CH3OH).

Workup

  1. filtrationFilter the resulting mixture
  2. customevaporate the solvent
  3. customtriturate the product with 1 liter of EtOH
  4. filtrationFilter
  5. customdry the product
  6. customto obtain
  7. wash51.6 gm of the title compound, Rf is 0.17 (silica gel plates eluted with 40% conc. NH3 /CH3OH)

Sources & evidence

ORD record
ord-d55dd12cfe95422c891660ba387ad9ac
Source dataset
uspto-grants-1998_05
Patent number
US05753714

Reaction notes

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