Diisopropylethylamine → HCID 18917760, compound

HRID 1291767Notes

Reaction equation

HRID 1291767 reaction equation
C1(C)C=CC(S(O)(=O)=O)=CC=1.[CH2:12]([O:19][C:20](=[O:23])[CH2:21][NH2:22])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[O:24]1[CH2:29][CH2:28][N:27]([C:30](Cl)=[O:31])[CH2:26][CH2:25]1.C(N(C(C)C)C(C)C)C>C(Cl)Cl>[CH2:12]([O:19][C:20](=[O:23])[CH2:21][NH:22][C:30]([N:27]1[CH2:28][CH2:29][O:24][CH2:25][CH2:26]1)=[O:31])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 848104-Morpholinecarbonyl chlorideHCID 6451311O-benzylglycine toluene-p-sulphonate

Product 1

HCID 18917760HCID 18917760, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Analogously to Example 7b), 7.69 g (22.8 mmol) of glycine-benzyl ester 4-toluenesulfonate and 2.8 g (19 mmol) of (morpholinocarbonyl)chloride in 118 ml of methylene chloride and 9 ml (53 mmol) of N-ethyldiisopropylamine are reacted for 18 h. The title compound is obtained in pure form after extraction with methylene chloride and digestion with hexane: tRet (I)=11.6 min.

Sources & evidence

ORD record
ord-ed769eddf9c248489c2af233f699a4d1
Source dataset
uspto-grants-1998_05
Patent number
US05753652

Reaction notes

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