Ethanol → HCID 86752613, compound

HRID 1292064Notes

Reaction equation

HRID 1292064 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]2[N:12]([C:13]=1[C:14](=O)[CH2:15]COC)[CH:11]=[CH:10][CH:9]=[CH:8]2)([O:3]C)=O.O.[NH2:21][NH2:22].[CH2:23]([OH:25])C>>[CH3:23][O:25][CH2:15][C:14]1[C:13]2[N:12]3[C:7]([CH:8]=[CH:9][CH:10]=[CH:11]3)=[CH:6][C:5]=2[C:1](=[O:3])[NH:22][N:21]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 86752614HCID 86752614, compound

Product 1

HCID 86752613HCID 86752613, compoundYield 97%

Procedure

A mixture of (IV) [7.06 g, 30.5 mmol] and excess 85% hydrazine hydrate in ethanol (300 mL) was heated under reflux (a precipitate formed). After cooling, the solid was collected by filtration and dried to give 4-methoxymethylpyridazino[4,5-b]indolizin-1-one (V, 6.81 g, 97%)

Workup

  1. temperaturewas heated
  2. temperatureunder reflux (a precipitate
  3. customformed)
  4. temperatureAfter cooling
  5. filtrationthe solid was collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-40c3c24f36b54f25852ede00bce0c489
Source dataset
uspto-grants-1998_05
Patent number
US05756501

Reaction notes

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