Hydrochloric Acid → HCID 18914238, compound

HRID 1292114Notes

Reaction equation

HRID 1292114 reaction equation
[F:1][C:2]1[CH:31]=[CH:30][C:5]([CH2:6][O:7][C:8]2[CH:25]=[CH:24][C:11]([C:12]([N:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH:21]([CH3:23])[CH3:22])[CH2:16][CH2:15]3)=[O:13])=[CH:10][C:9]=2[CH2:26][CH:27]([CH3:29])[CH3:28])=[CH:4][CH:3]=1.[ClH:32]>C(OCC)C>[ClH:32].[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][O:7][C:8]2[CH:25]=[CH:24][C:11]([C:12]([N:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH:21]([CH3:22])[CH3:23])[CH2:16][CH2:15]3)=[O:13])=[CH:10][C:9]=2[CH2:26][CH:27]([CH3:29])[CH3:28])=[CH:30][CH:31]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9888723HCID 9888723, compound

Product 1

HCID 18914238HCID 18914238, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

1-[4-(4-fluorobenzyloxy)-3-isobutylbenzoyl]-4-isobutylpiperazine (3.18 g) was dissolved in diethyl ether (20 ml) and then 15 ml of 1N hydrogen chloride in ether was added. After this mixture was stirred for 10 minutes at room temperature, the resulting crystals were collected by filtration, thereby yielding 4.40 g of the aimed compound.

Workup

  1. filtrationthe resulting crystals were collected by filtration

Sources & evidence

ORD record
ord-140103b651f643aba8c624c890de300c
Source dataset
uspto-grants-1998_05
Patent number
US05756505

Reaction notes

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