Aluminium lithium hydride → HCID 22857198, compound

HRID 129233Notes

Reaction equation

HRID 129233 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][C@@:8]12[C:18]3[C:19](S(C4C(C(C)C)=CC(C(C)C)=CC=4C(C)C)(=O)=O)=[CH:20][CH:21]=[C:22]4[NH:23][CH:24]=[C:16]([C:17]=34)[CH2:15][C@H:9]1[NH:10][C:11](=O)[CH2:12][O:13]2>C1COCC1>[CH3:7][C@@:8]12[C:18]3[CH:19]=[CH:20][CH:21]=[C:22]4[NH:23][CH:24]=[C:16]([C:17]=34)[CH2:15][C@H:9]1[NH:10][CH2:11][CH2:12][O:13]2

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 22857194HCID 22857194, compound

Product 1

HCID 22857198HCID 22857198, compoundYield 18.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Lithium aluminum hydride (5 equivalents) was allowed to react with a THF solution (20 ml) of trans-4,6,6a,8,9,10a-hexahydro-10a-methyl-1-(2,4,6-triisopropylphenylsulfonyl)-7H-indolo[3,4-gh][1.4]benzoxazin-8-one (1.2 g, 2.36 mmol). The residue thus obtained was subjected to a silica gel column chromatography, eluting with ethyl acetate, to afford 100 mg (15%) of the title compound.

Workup

  1. customThe residue thus obtained
  2. washeluting with ethyl acetate

Sources & evidence

ORD record
ord-df759e1f61cc4e99879594bf2b88c2a6
Source dataset
uspto-grants-1995_11
Patent number
US05466689

Reaction notes

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