Borane → HCID 21254087, compound

HRID 1292397Notes

Reaction equation

HRID 1292397 reaction equation
[CH2:1]([N:8]([CH2:33][CH2:34][CH2:35][CH2:36][C:37]1[CH:42]=[CH:41][C:40]([NH:43][S:44]([CH3:47])(=[O:46])=[O:45])=[CH:39][CH:38]=1)[C:9](=O)[C:10]([C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([N+:21]([O-:23])=[O:22])[CH:19]=2)[NH:14][C:13]=1[C:24]1[CH:29]=[C:28]([CH3:30])[CH:27]=[C:26]([CH3:31])[CH:25]=1)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.B>O1CCCC1>[CH2:1]([N:8]([CH2:9][CH2:10][C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([N+:21]([O-:23])=[O:22])[CH:19]=2)[NH:14][C:13]=1[C:24]1[CH:25]=[C:26]([CH3:31])[CH:27]=[C:28]([CH3:30])[CH:29]=1)[CH2:33][CH2:34][CH2:35][CH2:36][C:37]1[CH:42]=[CH:41][C:40]([NH:43][S:44]([CH3:47])(=[O:46])=[O:45])=[CH:39][CH:38]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6331BoraneHCID 21254044HCID 21254044, compound

Product 1

HCID 21254087HCID 21254087, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of N-benzyl-2-[2-(3,5-dimethylphenyl)-5-nitro-1H-indol-3-yl]-N-[4-(4-methanesulfonylaminophenyl)butyl]-2-oxo-acetamide (73 mg in 4 mL dry tetrahydrofuran) was added 1 mL of a 1M solution of borane in tetrahydrofuran and the mixture heated slowly to reflux on an oil bath.

Workup

  1. temperaturethe mixture heated slowly
  2. temperatureto reflux on an oil bath

Sources & evidence

ORD record
ord-b940e6691cbf43e5b8d4b3b502013abc
Source dataset
uspto-grants-1998_05
Patent number
US05756507

Reaction notes

Loading…