Sulfuric acid magnesium salt (1:1) → 3-amino-N-(1,1-dimethylethyl)-4-quinolinamine

HRID 1292476Notes

Reaction equation

HRID 1292476 reaction equation
[CH3:1][C:2]([NH:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[CH:8][C:7]=1[N+:16]([O-])=O)([CH3:4])[CH3:3].S([O-])([O-])(=O)=O.[Mg+2].[H][H]>[Pt].C(OCC)(=O)C>[NH2:16][C:7]1[CH:8]=[N:9][C:10]2[C:15]([C:6]=1[NH:5][C:2]([CH3:4])([CH3:3])[CH3:1])=[CH:14][CH:13]=[CH:12][CH:11]=2

Participants

6

Reactant 3

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 14986960HCID 14986960, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 149869613-amino-N-(1,1-dimethylethyl)-4-quinolinamine

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 17.7 g (0.0722 mole) of N-(1,1-dimethylethyl)-3-nitro-4-quinolinamine, 350 mL of ethyl acetate, 20 g of magnesium sulfate and about one gram of platinum on charcoal was hydrogenated on a Paar apparatus. After hydrogen pressure stabilized, the mixture was filtered and the filtrate was evaporated to provide a solid residue of 3-amino-N-(1,1-dimethylethyl)-4-quinolinamine.

Workup

  1. filtrationthe mixture was filtered
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-8787e7136e7e4815acd6f8f8d2daaead
Source dataset
uspto-grants-1998_05
Patent number
US05756747

Reaction notes

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