Hydrochloric Acid → HCID 131726507, compound

HRID 1292740Notes

Reaction equation

HRID 1292740 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[C@@H:13]([C@H:17]([NH:26]C(=O)OC(C)(C)C)[C:18]([N:20]2[CH2:24][CH2:23][C@H:22]([F:25])[CH2:21]2)=[O:19])[CH2:12][CH2:11]3)=[CH:4][CH:3]=1.[ClH:34]>O1CCOCC1>[ClH:34].[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[C@@H:13]([C@H:17]([NH2:26])[C:18]([N:20]2[CH2:24][CH2:23][C@H:22]([F:25])[CH2:21]2)=[O:19])[CH2:12][CH2:11]3)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131726508HCID 131726508, compound

Product 1

HCID 131726507HCID 131726507, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 24.5 mg of the compound from Step H in 1 mL of 4N hydrogen chloride in dioxane was stirred at ambient temperature for 1 h and then concentrated. The resultant solid was washed with ether and dried in vacuo to give the title compound. Mass spectrum (MS): m/z 357 (M+1).

Workup

  1. concentrationconcentrated
  2. washThe resultant solid was washed with ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-e0444ef7af524a67aa48ad9b25f90497
Source dataset
uspto-grants-2007_07
Patent number
US07238683B2

Reaction notes

Loading…