Water → HCID 58905132, compound

HRID 1292860Notes

Reaction equation

HRID 1292860 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:13]=2[F:19])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].N[C:21](N)=[O:22].O>CN1C(=O)CCC1>[F:19][C:13]1[CH:14]=[C:15]([F:18])[CH:16]=[CH:17][C:12]=1[O:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[NH:1][C:21](=[O:22])[NH:6][C:4]2=[O:5]

Participants

5

Reactant 3

HCID 962WaterHCID 1176UreaHCID 58905135HCID 58905135, compound

Product 1

HCID 58905132HCID 58905132, compoundYield 86.9%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Compound (1D) (23 g, 0.09 mol) and urea (25.42 g, 0.41 mol) in NMP (150 mL) were heated to 170° C. for 18 h. After cooling to room temperature, the reaction mixture was poured into water (200 mL) and stirred for 1 h. The precipitate was filtered, washed with water, and dried to afford 22.7 g of 6-(2,4-difluoro-phenoxy)-1H-quinazoline-2,4-dione (1E).

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-aebc251b0b9e4a1fba5fbf9fd931e2a6
Source dataset
uspto-grants-2007_07
Patent number
US07238698B2

Reaction notes

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