反应详情

Compound (1G) (21 g, 0.07 mol) was dissolved in THF (200 mL) and the solution added dropwise to a solution of t-butyl nitrite (16.5 mL, 0.14 mol) in THF (100 mL). The mixture was heated to reflux for 4 h, and after cooling to room temperature, the reaction mixture was poured into water and extracted with EtOAc (2×100 mL). The combined organic layers were dried over sodium sulfate and evaporated in vacuo. The crude product was purified by chromatography (silica gel, hexane: EtOAc, 4:1) giving 9.05 g of 2-chloro-6-(2,4-difluoro-phenoxy)-quinazoline (1H).

1. temperatureThe mixture was heated
2. temperatureto reflux for 4 h
3. extractionextracted with EtOAc (2×100 mL)
4. dry with materialThe combined organic layers were dried over sodium sulfate
5. customevaporated in vacuo
6. customThe crude product was purified by chromatography (silica gel, hexane: EtOAc, 4:1)