反应详情

温度

70 °C

To a solution of 5-nitroindazole (10.0 g, 61.3 mmol) in acetonitrile (100 mL) was added potassium carbonate (16.9 g, 122.6 mmol) and benzyl bromide (13.6 g, 79.7 mmol). The resulting yellow reaction mixture was heated with stirring at 70° C. overnight. Upon cooling down, the solid was filtered off and washed with methylene chloride. The filtrate was concentrated to dryness and the resulting residue was purified by flash chromatography eluting with 17–25% ethyl acetate in hexanes (v/v) yielding 7.0 g (44%) of the corresponding 1-Benzyl-5-nitro-1H-indazole as a yellow solid.

1. temperatureThe resulting yellow reaction mixture was heated
2. temperatureUpon cooling down
3. filtrationthe solid was filtered off
4. washwashed with methylene chloride
5. concentrationThe filtrate was concentrated to dryness
6. customthe resulting residue was purified by flash chromatography
7. washeluting with 17–25% ethyl acetate in hexanes (v/v)