反应详情

To a solution containing butynyl bromide (1 g, 7.5 mmol), hydroquinone (827 mg, 7.5 mmol), and K2CO3 (1.04 g, 7.5 mmol) was refluxed for 10 h. Solvent was removed in vacuo and the crude product was dissolved in EtOAc and partitioned with water. Organic layer was separated and washed with water and dried over anhydrous Na2SO4. The solvent was removed in vacuo to obtain the crude product (0.3 g, 25%), which was used for the next step without further purification; LCMS 99%, m/z 162.2 (M+).

1. temperaturewas refluxed for 10 h
2. customSolvent was removed in vacuo
3. dissolutionthe crude product was dissolved in EtOAc
4. custompartitioned with water
5. customOrganic layer was separated
6. washwashed with water
7. dry with materialdried over anhydrous Na2SO4
8. customThe solvent was removed in vacuo