Trimethylsilylacetylene → HCID 67000874, compound

HRID 1293725Notes

Reaction equation

[CH:1]1([C:4]2[C:5]3[N:6]([C:20](I)=[CH:21][N:22]=3)[CH:7]=[C:8]([C:10]3[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=3)[CH:9]=2)[CH2:3][CH2:2]1.[CH3:24][Si:25]([C:28]#[CH:29])([CH3:27])[CH3:26]>>[CH:1]1([C:4]2[C:5]3[N:6]([C:20]([C:29]#[C:28][Si:25]([CH3:27])([CH3:26])[CH3:24])=[CH:21][N:22]=3)[CH:7]=[C:8]([C:10]3[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=3)[CH:9]=2)[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 66111Trimethylsilylacetylene

HCID 67000884HCID 67000884, compound

Product 1

HCID 67000874HCID 67000874, compound

Procedure

Prepared from 8-cyclopropyl-3-iodo-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridine (example C.25 step 5) (3.1 g, 7 mmol) and trimethylsilylacetylene (2.00 mL, 14 mmol) as described in example C.20 step 4. Obtained the title compound as an amorphous brown material (2.3 g, 79%). MS (ISP) 399.2 [(M+H)+].

Sources & evidence

ORD record: ord-6b70e65de8744a7a9c8c2bc8bf33b49d
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07238808B2

Reaction notes

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