Hydrochloric Acid → HCID 86608104, compound

HRID 1293973Notes

Reaction equation

HRID 1293973 reaction equation
[C:1]([N:4]([C:8]1[N:13]=[CH:12][C:11]([C:14]#[C:15][C:16]2[CH:17]=[N:18][N:19]3[C:24]([C:25]([F:28])([F:27])[F:26])=[CH:23][C:22]([C:29]4[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:37])[F:36])=[CH:31][CH:30]=4)=[N:21][C:20]=23)=[CH:10][N:9]=1)C(=O)C)(=[O:3])[CH3:2].Cl.O>N.C1COCC1>[F:27][C:25]([F:26])([F:28])[C:24]1[N:19]2[N:18]=[CH:17][C:16]([C:15]#[C:14][C:11]3[CH:12]=[N:13][C:8]([NH:4][C:1](=[O:3])[CH3:2])=[N:9][CH:10]=3)=[C:20]2[N:21]=[C:22]([C:29]2[CH:34]=[CH:33][C:32]([C:35]([F:36])([F:37])[F:38])=[CH:31][CH:30]=2)[CH:23]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86608105HCID 86608105, compound

Product 1

HCID 86608104HCID 86608104, compoundYield 99.9%

Reagents, catalysts & solvents 2

HCID 222AmmoniaSolventHCID 8028TetrahydrofuranSolvent

Procedure

N-Acetyl-N-{5-[7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-pyrimidin-2-yl}-acetamide (example 244) (56 mg, 0.1 mmol) was dissolved in ammonia (200 uL) and THF (5 mL), stirred for 15 minutes at 23° C., then 1N HCl and water added until pH=1. The product was filtered off, washed with water and dried in vacuum to give the title compound as a yellow solid (49 mg, 95%). MS (ISP) 491.2 [(M+H)+]; mp 293° C.

Workup

  1. filtrationThe product was filtered off
  2. washwashed with water
  3. customdried in vacuum

Sources & evidence

ORD record
ord-d234aa688fb142c0b8feeb6718d88760
Source dataset
uspto-grants-2007_07
Patent number
US07238808B2

Reaction notes

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