反应详情

To a mixture of 4-[(5-methyl-2-phenyl-4-thiazolyl)methoxy]benzaldehyde (6.00 g), tetrahydrofuran (30 ml) and methanol (20 mL) was added sodium borohydride (0.38 g) under ice-cooling, and the mixture was stirred at room temperature for 30 min. Dilute hydrochloric acid and water were added to acidify the reaction mixture, and the precipitated solid was collected by filtration, and dried with air to give crystals (5.68 g, 94%) of [4-[(5-methyl-2-phenyl-4-thiazolyl)methoxy]phenyl]methanol. Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 94-95° C.

1. temperaturecooling
2. filtrationthe precipitated solid was collected by filtration
3. customdried with air