反应详情

To a mixture of methyl 2-(5-methyl-2-phenyl-4-oxazolyl)methoxy-4-pyridinecarboxylate (1.95 g) and tetrahydrofuran (20 mL) was added lithium aluminum hydride (0.228 g) under ice-cooling, and the mixture was stirred at room temperature for 30 min. Sodium sulfate 10 hydrate (1.93 g) was added to the mixture and the mixture was stirred at room temperature for 30 min. The insoluble materials were removed by filtration, and the filtrate was concentrated. The obtained crystals were recrystallized from ethyl acetate-hexane to give [2-(5-methyl-2-phenyl-4-oxazolylmethoxy)-4-pyridyl]methanol as colorless plate crystals (1.37 g, 77%). melting point: 100-101° C.

1. temperaturecooling
2. stirringthe mixture was stirred at room temperature for 30 min
3. customThe insoluble materials were removed by filtration
4. concentrationthe filtrate was concentrated
5. customThe obtained crystals were recrystallized from ethyl acetate-hexane