反应详情

A mixture of 4-methoxymethoxymethyl-2-phenyl-5-propyloxazole (2.64 g), 10% sulfuric acid (10 mL) and tetrahydrofuran (100 mL) was heated under reflux for 24 hrs. To the reaction mixture was added ethyl acetate, and the mixture was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate and concentrated to give (2-phenyl-5-propyl-4-oxazolyl)methanol as a colorless oil (2.10 g, 96%).

1. temperaturewas heated
2. temperatureunder reflux for 24 hrs
3. washthe mixture was washed successively with water and saturated brine
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated