Potassium Carbonate → HCID 13007955, compound

HRID 1294400Notes

Reaction equation

HRID 1294400 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].C(=O)([O-])[O-].[K+].[K+].[N:17]1([CH2:22][CH2:23][CH2:24][N:25]2[CH2:31][CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH2:21][CH2:20][CH2:19][CH2:18]1>O>[N+:8]([C:3]1[CH:4]=[CH:5][C:6]([N:28]2[CH2:29][CH2:30][CH2:31][N:25]([CH2:24][CH2:23][CH2:22][N:17]3[CH2:18][CH2:19][CH2:20][CH2:21]3)[CH2:26][CH2:27]2)=[CH:7][CH:2]=1)([O-:10])=[O:9]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 738951-Fluoro-2-nitrobenzeneHCID 27372511-[3-(pyrrolidin-1-yl)propyl]-1,4-diazepane

Product 1

HCID 13007955HCID 13007955, compoundYield 95.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Fluoronitrobenzene (5.56 g, 39.43 mmol) is dissolved in water, and then potassium carbonate (6.55 g, 47.31 mmol) and 1-(3-pyrrolidinopropyl)-homopiperazine (10 g, 47.31 mmol) are added. The medium is heated at 85° for 4 hours and then cooled to room temperature. The medium is filtered and a yellow solid is recovered after drying in a vacuum oven at 45° C. (12.5 g, yield=95.5%).

Workup

  1. temperatureThe medium is heated at 85° for 4 hours
  2. filtrationThe medium is filtered
  3. customa yellow solid is recovered
  4. customafter drying in a vacuum oven at 45° C. (12.5 g, yield=95.5%)

Sources & evidence

ORD record
ord-c9a8c03537d246feb7c071f9bc17f2e0
Source dataset
uspto-grants-2007_07
Patent number
US07241317B2

Reaction notes

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