Potassium Carbonate → HCID 13007959, compound

HRID 1294402Notes

Reaction equation

HRID 1294402 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].C(=O)([O-])[O-].[K+].[K+].[OH:17][CH2:18][CH2:19][N:20]1[CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>O>[N+:8]([C:3]1[CH:4]=[CH:5][C:6]([N:23]2[CH2:24][CH2:25][CH2:26][N:20]([CH2:19][CH2:18][OH:17])[CH2:21][CH2:22]2)=[CH:7][CH:2]=1)([O-:10])=[O:9]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 738951-Fluoro-2-nitrobenzeneHCID 27365502-(1,4-Diazepan-1-yl)ethan-1-ol

Product 1

HCID 13007959HCID 13007959, compoundYield 91.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
95 °C

Procedure

Fluoronitrobenzene (2.03 g, 14.4 mmol) is dissolved in water (10 ml), and then potassium carbonate (2.4 g, 17.3 mmol) and 1-(2-hydroxyethyl)-homopiperazine are added. The medium is heated at 95° C. for 4 hours and then cooled to room temperature and filtered. A dark orange-coloured powder is recovered which is placed in the oven (3.5 g, yield=91.7%).

Workup

  1. temperaturecooled to room temperature
  2. filtrationfiltered
  3. customA dark orange-coloured powder is recovered which

Sources & evidence

ORD record
ord-42aa3a42d33a4141a14469808b5fe89d
Source dataset
uspto-grants-2007_07
Patent number
US07241317B2

Reaction notes

Loading…