反应详情

The product of Example 16A (100 mg, 0.26 mmol) in ethyl acetate (4 mL) was treated with trifluroacetic acid (113 mg, 1 mmol). The title compound was obtained as solid (100 mg, yield, 64%). 1H NMR (MeOH-d4, 300 MHz) δ 1.85–2.16 (m, 3H), 2.25–2.46 (m, 1H), 2.56 (m, 1H), 3.30–3.53 (m, 5H), 3.80 (m, 1H), 4.95 (m, 1H), 7.04 (dt, J=9.1, 2.4 Hz, 2H), 7.14 (dt, J=9.1, 2.3 Hz, 2H), 8.60 (s, 2H) ppm. MS (DCl/NH3) m/z. m/z 376 (M+H)+, 378 (M+H)+. Anal. Calculated for C17H18BrN3O2.2.0CF3CO2H.2.0H2O: C, 39.39; H, 3.78; N, 6.56. Found: C, 39.19; H, 3.78; N, 6.83.