反应详情

The product of Example 19A (110 mg, 0.37 mmol) in ethyl acetate (5 mL) was treated with 4M HCl in 1,4-dioxane (0.5 mL, 2 mmol). The title compound was obtained as a solid (130 mg, yield, 96%). 1H NMR (MeOH-d4, 300 MHz) δ 1.85–2.18 (m, 3H), 2.25–2.40 (m, 1H), 2.50–2.58 (m, 1H), 3.30–3.50 (m, 5H), 3.78–3.8(m, 1H), 4.92 (m, 1H), 7.08 (dt, J=8.9, 3.7 Hz, 2H), 7.26 (dt, J=9.2, 3.7 Hz, 2H), 7.78 (dd, J=8.9, 5.5 Hz, 1H), 7.93 (ddd, J=8.8, 2.7, 1.4 Hz, 1H), 8.06 (dt, J=5.4, 1.0 Hz, 1H), 8.17 (d, J=3.1 Hz, 1H) ppm. MS (DCl/NH3) m/z 296 (M+H)+. Anal. Calculated for C18H21N3O.2.0HCl.1.1H2O: C, 55.70; H, 6.54; N, 10.83. Found: C, 55.55; H, 6.28; N, 11.09.