O-Methylhydroxylamine hydrochloride → HCID 86093123, compound

HRID 1294708Notes

Reaction equation

HRID 1294708 reaction equation
[N:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[C:13](=O)[CH3:14])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl.[CH3:17][O:18][NH2:19]>N1C=CC=CC=1.C(OCC)(=O)C>[CH3:17][O:18][N:19]=[C:13]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1)[CH3:14]

Participants

5

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 142678081-[2-(Morpholin-4-yl)phenyl]ethan-1-one

Product 1

HCID 86093123HCID 86093123, compoundYield 93.4%

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of Example 49A (1.22 g, 5.94 mmol) and methoxyamine hydrochloride (550 mg, 6.59 mmol) in pyridine (20 mL) was stirred at room temperature for 12 h. The reaction was diluted with ethyl acetate and washed sequentially with 3 N HCl, 1 N HCl and brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated to dryness under reduced pressure to give 1.3 g of the title compound. MS (ESI+) m/z 235 (M+H)+.

Workup

  1. washwashed sequentially with 3 N HCl, 1 N HCl and brine
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-c8ba335ca5ed4a5ba5d22c9fd6b9ecaa
Source dataset
uspto-grants-2007_07
Patent number
US07241776B2

Reaction notes

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