反应详情

A mixture of 4-(4-sulfophenyl)-3-thiosemicarbazide, sodium salt (740 mg, 2.75 mmol), 3,5-dichloro-2-hydroxybenzaldehyde (577 mg, 3.02 mmol), concentrated aqueous hydrochloric acid (0.3 mL) and ethanol (10 mL) was heated under reflux for 20 min. then cooled. The solid was filtered, washed (water) and dried to give the title compound (277 mg, 24%) as a solid. MS (ES−) m/e 418, 420 [M−H]−.

1. temperaturewas heated
2. temperatureunder reflux for 20 min.
3. temperaturethen cooled
4. filtrationThe solid was filtered
5. washwashed (water)
6. customdried