Hydrochloric Acid → HCID 136333621, compound

HRID 1294721Notes

Reaction equation

HRID 1294721 reaction equation
[S:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[S:15])[NH:13][NH2:14])=[CH:7][CH:6]=1)([OH:4])(=[O:3])=[O:2].[Na].[Cl:17][C:18]1[C:19]([OH:27])=[C:20]([CH:23]=[C:24]([Cl:26])[CH:25]=1)[CH:21]=O.Cl>C(O)C>[Cl:17][C:18]1[C:19]([OH:27])=[C:20]([CH:23]=[C:24]([Cl:26])[CH:25]=1)[CH:21]=[N:14][NH:13][C:12]([NH:11][C:8]1[CH:7]=[CH:6][C:5]([S:1]([OH:4])(=[O:2])=[O:3])=[CH:10][CH:9]=1)=[S:15]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 666603,5-DichlorosalicylaldehydeHCID 5360545SodiumHCID 11053969HCID 11053969, compound

Product 1

HCID 136333621HCID 136333621, compoundYield 24%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4-(4-sulfophenyl)-3-thiosemicarbazide, sodium salt (740 mg, 2.75 mmol), 3,5-dichloro-2-hydroxybenzaldehyde (577 mg, 3.02 mmol), concentrated aqueous hydrochloric acid (0.3 mL) and ethanol (10 mL) was heated under reflux for 20 min. then cooled. The solid was filtered, washed (water) and dried to give the title compound (277 mg, 24%) as a solid. MS (ES−) m/e 418, 420 [M−H]−.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 20 min.
  3. temperaturethen cooled
  4. filtrationThe solid was filtered
  5. washwashed (water)
  6. customdried

Sources & evidence

ORD record
ord-1d3c3d1d927348748c490046510b9c2f
Source dataset
uspto-grants-2007_07
Patent number
US07241783B2

Reaction notes

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