HRID1294732

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

HCID3693046

4-(Pyridin-3-yl)benzaldehyde

C12H9NO

结构：CCN(CC)C(=O)c1ccc(C(c2cccc(N)c2)N2CCN(C(=O)OC(C)(C)C)CC2)cc1

HCID11590834

未命名化合物

HCID178419135

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)C(=O)c1ccc([C@@H](c2cccc(NCc3ccc(-c4cccnc4)cc3)c2)N2CCNCC2)cc1

HCID10392326

未命名化合物

收率 113.3%

PROCEDURE

实验过程

Using the same method as for COMPOUND 17 and using INTERMEDIATE 5a (205 mg, 0.44 mmol), 4-(3-pyridinyl)benzaldehyde (88.7 mg, 0.48 mmol), and decaborane (16.4 mg, 0.13 mmol) afforded COMPOUND 52 (266 mg, 61% yield) as its TFA salt. This material was lyophilized from CH3CN/H2O to produce a slightly yellow solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-61407ac0d4724b6e936ac46ea9f803fc
来源数据集: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07241764B2
来源说明: uspto-grants-2007_07

反应 SMILES

[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]([C:22]2[CH:27]=[CH:26][C:25]([C:28]([N:30]([CH2:33][CH3:34])[CH2:31][CH3:32])=[O:29])=[CH:24][CH:23]=2)[N:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[CH:5]=[CH:6][CH:7]=1.[N:35]1[CH:40]=[CH:39][CH:38]=[C:37]([C:41]2[CH:48]=[CH:47][C:44]([CH:45]=O)=[CH:43][CH:42]=2)[CH:36]=1.[B][B][B][B][B][B][B][B][B][B].C(O)(C(F)(F)F)=O>>[CH2:33]([N:30]([CH2:31][CH3:32])[C:28](=[O:29])[C:25]1[CH:24]=[CH:23][C:22]([C@@H:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([NH:1][CH2:45][C:44]3[CH:43]=[CH:42][C:41]([C:37]4[CH:36]=[N:35][CH:40]=[CH:39][CH:38]=4)=[CH:48][CH:47]=3)[CH:3]=2)[N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:27][CH:26]=1)[CH3:34]