3-bromo-2-fluoro-N-methoxy-N-methylbenzamide → (3-Bromo-2-fluorophenyl)(4-methoxy-2-methylphenyl)methanone

HRID 1294875Notes

Reaction equation

HRID 1294875 reaction equation
[Br:1][C:2]1[C:3]([F:14])=[C:4]([CH:11]=[CH:12][CH:13]=1)[C:5](N(OC)C)=[O:6].[CH3:15][C:16]1[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][C:17]=1[Mg]Br>C1COCC1>[Br:1][C:2]1[C:3]([F:14])=[C:4]([C:5]([C:17]2[CH:18]=[CH:19][C:20]([O:22][CH3:23])=[CH:21][C:16]=2[CH3:15])=[O:6])[CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 578252533-bromo-2-fluoro-N-methoxy-N-methylbenzamideHCID 178491917HCID 178491917, compound

Product 1

HCID 68883872(3-Bromo-2-fluorophenyl)(4-methoxy-2-methylphenyl)methanone

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared according to Method A step B from 3-bromo-2-fluoro-N-methoxy-N-methylbenzamide (8 g, 31 mmol) and 2-methyl-4-methoxyphenyl magnesium bromide ((70 ml, 0.5 M in THF) to give 3.58 g of the title compound.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-97321b99fd034ecaae22f29428ec289e
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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