Hydrazine hydrate (1:1) → HCID 178489134, compound

HRID 1294906Notes

Reaction equation

HRID 1294906 reaction equation
F[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1)=O.O.[NH2:23][NH2:24]>CN(C1C=CN=CC=1)C>[CH3:21][O:20][C:17]1[CH:18]=[CH:19][C:14]([C:12]2[C:3]3[C:2](=[C:7]([C:8]([F:11])([F:10])[F:9])[CH:6]=[CH:5][CH:4]=3)[NH:24][N:23]=2)=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 11231817(2-Fluoro-3-trifluoromethyl-phenyl)-(4-methoxy-phenyl)-methanone

Product 1

HCID 178489134HCID 178489134, compoundYield 39.6%

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

Prepared according to Method D Step A from (2-Fluoro-3-trifluoromethylphenyl)-(4-methoxyphenyl)-methanone (3.6 g, 14.7 mmol), hydrazine hydrate (4.3 mL, 140 mmol) and DMAP (1.8 g, 14.7 mmol) to give the product (1.7 g) as a yellow solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0a1981e4da0c41f29400f186a96b9fbc
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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