Hydrazine hydrate (1:1) → HCID 178489137, compound

HRID 1294907Notes

Reaction equation

HRID 1294907 reaction equation
[Cl:1][C:2]1[C:3](F)=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=O)[CH:5]=[CH:6][CH:7]=1.O.[NH2:20][NH2:21]>CN(C1C=CN=CC=1)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[NH:21][N:20]=[C:8]2[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 11471075(3-Chloro-2-fluorophenyl)-(4-methoxyphenyl)-methanone

Product 1

HCID 178489137HCID 178489137, compoundYield 90.6%

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

Prepared according to Method D Step A from (3-chloro-2-fluoro-phenyl)-(4-methoxyphenyl)-methanone (0.84 g, 3.2 mmol), hydrazine hydrate (1.0 mL, 32 mmol) and DMAP (0.39 g, 3.2 mmol) to give the product (0.75 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-13cb5de5fcdf423bb3b69bb820f90907
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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