Hydrazine hydrate (1:1) → HCID 178489143, compound

HRID 1294909Notes

Reaction equation

HRID 1294909 reaction equation
F[C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([CH3:19])[CH:12]=1)=O.O.[NH2:21][NH2:22]>CN(C1C=CN=CC=1)C>[F:8][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]2[C:2]=1[NH:22][N:21]=[C:9]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([CH3:19])[CH:12]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 55101193(2,3-Difluorophenyl)-(4-methoxy-3-methyl-phenyl)-methanone

Product 1

HCID 178489143HCID 178489143, compoundYield 90.5%

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

Prepared according to Method D Step A from (2,3-difluorophenyl)-(4-methoxy-3-methyl-phenyl)-methanone (0.9 g, 3.45 mmol), hydrazine hydrate (1.06 mL, 34 mmol) and DMAP (0.42 g, 3.45 mmol) to give the product (0.80 g) as a yellow solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-22a7a56647334e76acde19b69193d0e0
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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