Sodium hydride → HCID 68883555, compound

HRID 1294921Notes

Reaction equation

HRID 1294921 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[C:13]([CH3:18])[CH:14]=[CH:15][CH:16]=3)[NH:11][N:10]=2)=[CH:5][CH:4]=1.[H-].[Na+].I[CH2:22][CH2:23][CH3:24]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]([CH2:22][CH2:23][CH3:24])[N:11]=[C:12]3[C:17]=2[CH:16]=[CH:15][CH:14]=[C:13]3[CH3:18])=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 336431-IodopropaneHCID 178489133HCID 178489133, compound

Product 1

HCID 68883555HCID 68883555, compoundYield 10%

Procedure

Prepared according to Method D step B from 3-(4-methoxyphenyl)-7-methyl-1H-indazole (0.115 g, 0.5 mmol), sodium hydride (60% in oil, 0.024 g, 0.6 mmol) and 1-iodopropane (0.098 mL, 1.0 mmol) to give the title compound (0.014 g). Used as is in the next step.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c85afc90317c4c62af21a0c9687bdeaa
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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