Sodium hydride → HCID 68882935, compound

HRID 1294931Notes

Reaction equation

HRID 1294931 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1.[H-].[Na+].I[CH2:22][CH2:23][CH3:24]>>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:22][CH2:23][CH3:24])[N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 336431-IodopropaneHCID 178489137HCID 178489137, compound

Product 1

HCID 68882935HCID 68882935, compoundYield 53.9%

Procedure

Prepared according to Method D step B from 7-chloro-3-(4-methoxyphenyl)-1H-indazole (0.129 g, 0.5 mmol), sodium hydride (60% in oil, 0.024 g, 0.6 mmol) and 1-iodopropane (0.098 mL, 1.0 mmol) to give the title compound (0.081 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6873f585ca8548eba7fcd030e7638f0b
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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