1-Iodopentane → HCID 68882051, compound

HRID 1294938Notes

Reaction equation

HRID 1294938 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:14]=[CH:15][CH:16]=3)[NH:11][N:10]=2)=[CH:5][CH:4]=1.[H-].[Na+].I[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:17]3[C:12](=[C:13]([C:18]([F:21])([F:19])[F:20])[CH:14]=[CH:15][CH:16]=3)[N:11]([CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[N:10]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 123351-IodopentaneHCID 24758Sodium hydrideHCID 178489134HCID 178489134, compound

Product 1

HCID 68882051HCID 68882051, compoundYield 37.5%

Procedure

Prepared according to Method D step B from 3-(4-methoxyphenyl)-7-trifluoromethyl-1H-indazole (0.146 g, 0.5 mmol), sodium hydride (60% in oil, 0.024 g, 0.6 mmol) and 1-iodopentane (0.130 mL, 1.0 mmol) to give the title compound (0.068 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3dac0f7c35b043bf922681ef9b9b7eb2
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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