Sodium hydride → 7-chloro-3-(4-methoxyphenyl)-1-(3,3,3-trifluoropropyl)-1H-indazole

HRID 1294966Notes

Reaction equation

HRID 1294966 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1.[H-].[Na+].[F:21][C:22]([F:27])([F:26])[CH2:23][CH2:24]I>>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:24][CH2:23][C:22]([F:27])([F:26])[F:21])[N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 1561651,1,1-Trifluoro-3-iodopropaneHCID 178489137HCID 178489137, compound

Product 1

HCID 688861447-chloro-3-(4-methoxyphenyl)-1-(3,3,3-trifluoropropyl)-1H-indazoleYield 5.6%

Procedure

Prepared according to Method D step B from 7-chloro-3-(4-methoxyphenyl)-1H-indazole (0.108 g, 0.4 mmol), sodium hydride (60% in oil, 0.016 g, 0.4 mmol) and 3,3,3-trifluoropropyliodide (0.047 mL, 0.4 mmol) to give the title compound (0.008 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-80155674fff948c4af8a2a52883bc3fa
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

Loading…