Bromocyclopentane → 1-cyclopentyl-7-fluoro-3-(4-methoxy-3-methylphenyl)-1H-indazole

HRID 1294967Notes

Reaction equation

HRID 1294967 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([CH3:19])[CH:12]=1.[H-].[Na+].[CH:22]1(Br)[CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH:22]1([N:9]2[C:10]3[C:6](=[CH:5][CH:4]=[CH:3][C:2]=3[F:1])[C:7]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([CH3:19])[CH:12]=3)=[N:8]2)[CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

4

Reactant 3

HCID 8728BromocyclopentaneHCID 24758Sodium hydrideHCID 178489143HCID 178489143, compound

Product 1

HCID 688847601-cyclopentyl-7-fluoro-3-(4-methoxy-3-methylphenyl)-1H-indazoleYield 578%

Procedure

Prepared according to Method D step B from 7-fluoro-3-(4-methoxy-3-methylphenyl)-1H-indazole (0.76 g, 0.4 mmol), sodium hydride (60% in oil, 0.120 g, 3.0 mmol) cyclopentyl bromide (0.321 mL, 3.0 mmol) to give the title compound (0.75 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-40d10321724c48478154814ebdc76675
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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