1-Iodopentane → HCID 68884986, compound

HRID 1294979Notes

Reaction equation

HRID 1294979 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[C:15]([C:20]([F:23])([F:22])[F:21])[CH:16]=[CH:17][CH:18]=2)[NH:13][N:12]=1.[H-].[Na+].I[CH2:27][CH2:28][CH2:29][CH2:30][CH3:31]>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[C:15]([C:20]([F:23])([F:22])[F:21])[CH:16]=[CH:17][CH:18]=2)[N:13]([CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[N:12]=1

Participants

4

Reactant 3

HCID 123351-IodopentaneHCID 24758Sodium hydrideHCID 178489136HCID 178489136, compound

Product 1

HCID 68884986HCID 68884986, compoundYield 35.9%

Procedure

Prepared according to Method D step B from 3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole (0.150 g, 0.49 mmol), sodium hydride (60% in oil, 0.025 g, 1.04 mmol) and 1-iodopentane (0.07 mL, 0.7 mmol) to give the title compound (0.069 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-24aded73755749a8bb26bccfc7132a9e
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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