Sodium hydride → HCID 68885969, compound

HRID 1295011Notes

Reaction equation

HRID 1295011 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=1[CH3:19].[H-].[Na+].I[CH2:23][CH2:24][CH3:25]>>[F:1][C:2]1[C:10]2[C:6](=[C:7]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=3[CH3:19])[N:8]([CH2:23][CH2:24][CH3:25])[N:9]=2)[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 336431-IodopropaneHCID 178489144HCID 178489144, compound

Product 1

HCID 68885969HCID 68885969, compoundYield 45.8%

Procedure

Prepared according to Method D step B from 7-fluoro-3-(4-methoxy-2-methylphenyl)-1H-indazole (0.150 g, 0.52 mmol), sodium hydride (60% in oil, 0.025 g, 1.04 mmol) and 1-iodopropane (0.075 mL, 0.7 mmol) to give the title compound (0.071 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-009b3cf85fc14536a08cab9ed56e1000
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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