Sodium hydride → 3-(2,4-dimethoxyphenyl)-7-fluoro-1-propyl-1H-indazole

HRID 1295025Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[C:15]([F:20])[CH:16]=[CH:17][CH:18]=2)[NH:13][N:12]=1.[H-].[Na+].I[CH2:24][CH2:25][CH3:26]>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[C:15]([F:20])[CH:16]=[CH:17][CH:18]=2)[N:13]([CH2:24][CH2:25][CH3:26])[N:12]=1

Participants

Reactant 3

HCID 24758Sodium hydride

HCID 336431-Iodopropane

HCID 1784891453-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole

Product 1

HCID 688850303-(2,4-dimethoxyphenyl)-7-fluoro-1-propyl-1H-indazoleYield 99.2%

Procedure

Prepared according to Method D step B from 3-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole (0.300 g, 1.10 mmol), sodium hydride (60% in oil, 0.058 g, 1.50 mmol) and iodopropane (0.195 mL, 2.00 mmol) to give the title compound (0.343 g) as a white solid.

Workup

customPrepared

Sources & evidence

ORD record: ord-e2047550493a40b2943db28d4f058572
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07241791B2

Reaction notes

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